Uppgift
A) Name two allosteric regulators of oxygen binding to hemoglobin.
B) Explain an outcome for each regulator.
(Max 100 words.) Please answer this question in English. (4p)
Answer
a) O₂ and CO₂
b)
O₂:
Hemoglobin has four subunits that bind to O₂ through cooperativity, meaning that if one subunit binds to an O₂, the other subunits' affinity for O₂ will increase, leading to all subunits binding to O₂. When O₂ binds, the state goes from T-state (deoxy; tense) to R-state (oxy; relaxed).
CO₂:
When CO₂ binds to hemoglobin, the hemoglobin's affinity to oxygen decreases, leading to a stabilization of the T-state instead.
Totalpoäng: 4